Knight-ADRC study info: The Memory and Aging Project at the Charles F. And Joanne Knight Alzheimer’s Disease Research Center (Knight-ADRC at Washington University in St. Louis) collects collects plasma, CSF, fibroblast, neuroimaging clinical and cognition data longitudinally and autopsied brain samples. This clinical information combined with deep molecular phenotyping (i.e. genetic, proteomics, transcriptomics and others) will lead to the identification of novel genetic modifiers, protective variants, molecular biomarkers and the novel targets. Participants were recruited by the Knight-ADRC at Washington University in St. Louis (MO). Knight-ADRC participants have to be at least 65 years old and have no memory problems or mild dementia at the time of enrollment.