MAGENTA study info

MAGENTA study info #

Multi-Ancestry Genomics, Epigenomics, and Transcriptomics of Alzheimer’s (MAGENTA) Project: Participants include 465 individuals (AA – 113 with AD, 118 cognitively intact controls; NHW – 116 with AD, 118 controls) ascertained by the John P. Hussman Institute for Human Genomics (HIHG) at the University of Miami Miller School of Medicine (Miami, FL), North Carolina A&T State University (Greensboro, NC), and Case Western Reserve University (Cleveland, OH). Participants were ascertained as part of the ADSP Follow-up Study and included both cases (>65 years of age of onset) and controls (>65 years of age at age of exam). All participants were adjudicated by a clinical panel with expertise in AD related disorders and classified as AD according to standard criteria developed by the National Institute of Aging and the Alzheimer’s Association.

  • PI : Dr. William S. Bush; Dr. Margaret A. Pericak-Vance; Dr. Jonathan L. Haines, Dr. Goldie Byrd, Dr. Anthony J. Griswold
  • Institution : Case Western Reserve University; Wake Forest University, University of Miami
  • Grant number : RF1AG070935, RF1AG054074, U01AG052410
  • Contact person : Dr. William S. Bush ( wsb36@case.edu); Anthony J. Griswold (Griswold, Anthony J agriswold@miami.edu)
  • Publication : PMID: 32597797
  • Acknowledgement : This work was funded by NIH/NIA grants RF1AG070935, U01AG052410 and RF1AG054074. We thank the Alzheimer’s disease community including patients and family members who agreed to participate in the study and make this research possible. We acknowledge the Center for Genome Technology of the John P. Hussman Institute for Human Genomics for performing RNA extraction, storage and allocation and for performing RNA library preparation and sequencing.
  • Study name : Multi-Ancestry Genomics, Epigenomics, and Transcriptomics of Alzheimer’s (MAGENTA) Project
  • Study Description : MAGENTA is a cross-sectional study of Alzheimer’s disease that includes multiple ancestry groups. Using whole-blood as a source tissue, bulk RNA-seq and DNA methylation array data were generated and combined with existing genome-wide genotyping and whole-genome sequencing data. This study was designed to examine differences in -omics profiles between AD cases and controls by ancestry, and to discover eQTL and mQTL variants associated with AD outcomes.
  • Disease : Alzheimer’s disease
  • Website&Logo :
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  • Additional study information : NR